6,132,718 Multi-stage cascade boosting vaccine 6,130,364 Production of antibodies using Cre-mediated site-specific recombination 6,130,316 Fusion proteins of novel CTLA4/CD28 ligands and uses therefore 6,127,598 NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depression, and obesity 6,121,415 ErbB4 receptor-specific neuregolin related ligands and uses therefor 6,121,030 CSAPK-2 protein and uses therefor 6,118,045 Lysosomal proteins produced in the milk of transgenic animals 6,117,654 Nucleic acid molecules encoding Tango-77-polypeptides 6,117,650 Assay for cardiac hypertrophy 6,114,598 Generation of xenogeneic antibodies 6,114,123 Lipocalin family protein 6,111,092 Nucleic acid molecules encoding DRT111 and uses thereof 6,110,739 Method to produce novel embryonic cell populations 6,110,718 Mammalian putative phosphatidylinositol-4-phosphate-5-kinase 6,107,543 Culture of totipotent embryonic inner cells mass cells and production of bovine animals 6,107,472 Receptor-type tyrosine kinase-like molecules 6,107,088 XAF genes and polypeptides: methods and reagents for modulating apoptosis 6,106,832 Treatment of individuals exhibiting defective CD40L 6,103,890 Enzymatic nucleic acids that cleave C-fos 6,103,523 Pluripotent rabbit cell lines and method of making 6,100,445 Transgenic knockout mouse having functionally disrupted interleukin-1.beta. converting enzyme gene 6,100,444 Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen 6,100,443 Universal donor cells 6,093,545 Methods for detecting nucleic acid molecules encoding a member of the muscarinic family of receptors 6,093,393 Methods for preparing and using clonogenic fibroblasts and transfected clonogenic fibroblasts 6,091,001 Production of antibodies using Cre-mediated site-specific recombination 6,090,629 Efficient construction of gene targeting using phage-plasmid recombination 6,090,622 Human embryonic pluripotent germ cells 6,090,561 NF-AT-interacting protein NIP45 and methods of use therefor 6,090,381 Stimulation of an immune response with antibodies labeled with the . .alpha-galactosyl epitope 6,087,555 Mice lacking expression of osteoprotegerin 6,087,166 Transcriptional activators with graded transactivation potential 6,087,107 Therapeutics and diagnostics for congenital heart disease based on a novel human transcription factor 6,086,900 Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes 6,084,084 Human metabotropic glutamate receptor 6,084,067 CTLA4/CD28 ligands and uses therefor 6,083,911 Arenavirus receptor and methods of use 6,080,911 Mice models of growth hormone insensitivity 6,080,910 Transgenic knockout animals lacking IgG3 6,080,550 Isolation and characterization of Agouti: a diabetes/obesity related gene 6,077,990 PAR2 modified transgenic mice 6,077,936 Multidrug resistance-associated polypeptide 6,077,686 Shc proteins 6,077,675 Human metabotropic glutamate receptor 6,077,667 Method for chromosomal rearrangement by consecutive gene targeting of two recombination substrates to the deletion endpoints 6,075,181 Human antibodies derived from immunized xenomice 6,074,849 Polynucleotides encoding human CTLA-8 related proteins 6,074,845 Nucleic acid encoding a bovine calcitonin receptor-like receptor (BECRLR) 6,069,297 Glucose-6-phosphate dehydrogenase deficient mice and methods of using same 6,069,010 High throughput gene inactivation with large scale gene targeting 6,066,778 Transgenic mice expressing APC resistant factor V 6,063,983 Monoclonal lymphocytes and methods of use 6,063,359 Method for determining oncogenic activity of a substance 6,060,642 Serotonin 5-HT6 receptor knockout mouse 6,060,590 Chitinase related proteins and methods of use 6,060,310 Transcription factor decoy and tumor growth inhibitor 6,060,263 Mammalian lysophosphatidic acid acyltransferase 6,057,489 MmRad51-deficient cells and transgenic mice 6,057,128 MU-1, member of the cytokine receptor family 6,054,575 Mammalian telomerase RNA gene promoter 6,051,690 NSP molecules 6,051,688 Isolated human metabotropic glutamate receptor Mglur-8 6,051,403 Nsp molecules 6,046,048 Apo-2 ligand 6,046,035 Polynucleotides encoding a cardiotrophin-like cytokine 6,043,344 Human CTLA-8 and uses of CTLA-8-related proteins 6,043,040 Csak-3 nucleic acid molecules and uses therefor 6,037,168 Microbiological assembly comprising resealable closure means 6,037,148 MTBX protein and nucleic acid molecules and uses therefor 6,034,062 Bone morphogenetic protein (BMP)-9 compositions and their uses 6,033,861 Methods for obtaining nucleic acid containing a mutation 6,031,088 Polycystic kidney disease PKD2 gene and uses thereof 6,031,078 MTbx protein and nucleic acid molecules and uses therefor 6,031,003 Calcium receptor-active molecules 6,030,833 Transgenic swine and swine cells having human HLA genes 6,030,617 Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation 6,028,244 Defective platelet activation in G.alpha..sub.q deficient mice 6,028,243 Mice and cells with a homozygous disruption in the RNase L gene and methods therefore 6,028,184 Pax6 and Pax4 nucleic acid mixtures 6,027,917 Bone morphogenetic protein (BMP)-17 and BMP-18 compositions 6,025,157 Neurturin receptor 6,022,708 Fused 6,020,194 DNA encoding a Myt1 polypeptide 6,015,671 Myocardial grafts and cellular compositions 6,015,670 Methods for identifying a mutation in a gene of interest without a phenotypic guide using ES cells 6,015,554 Method of reconstituting human lymphoid and dendritic cells 6,013,468 RNA component of telomerase 6,011,197 Method of cloning bovines using reprogrammed non-embryonic bovine cells 6,011,068 Calcium receptor-active molecules 6,010,853 Siva genes, novel genes involved in CD27-mediated apoptosis 6,008,434 Growth differentiation factor-11 transgenic mice 6,004,941 Methods for regulating gene expression 6,002,066 H2-M modified transgenic mice 6,001,588 Introns and exons of the cystic fibrosis gene and mutations thereof 5,998,204 Fluorescent protein sensors for detection of analytes 5,998,187 Receptor tyrosine kinase 5,998,136 Selection systems and methods for identifying genes and gene products involved in cell proliferation 5,994,620 Induced chromosomal deletion 5,994,619 Production of chimeric bovine or porcine animals using cultured inner cell mass cells 5,994,618 Growth differentiation factor-8 transgenic mice 5,994,523 Melanoma antigens and their use in diagnostic and therapeutic methods 5,994,130 Multidrug resistance-associated polypeptide 5,994,075 Methods for identifying a mutation in a gene of interest without a phenotypic guide 5,990,281 Vertebrate smoothened proteins 5,989,914 Integration cassette for improvement of transgenesis in eukaryotes 5,986,056 Chordin compositions 5,985,660 Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation 5,985,659 Embryonic stem cell lines obtained from C3H/HeN and DBA/1J mouse strains 5,985,615 Directed switch-mediated DNA recombination 5,985,602 Secreted proteins and polynucleotides encoding them 5,981,830 Knockout mice and their progeny with a disrupted hepsin gene 5,981,277 Polypeptides and peptides, nucleic acids coding for them, and their use in the field of tumor therapy, inflammation or immunology
6,238,429 Biologic cabling 6,235,970 CICM cells and non-human mammalian embryos prepared by nuclear transfer of a proliferating differentiated cell or its nucleus 6,235,969 Cloning pigs using donor nuclei from non-quiescent differentiated cells 6,235,878 Fas ligand-like protein, its production and use 6,235,708 Testis-specific cystatin-like protein cystatin T 6,235,481 Polynucleotides encoding calpain 10 6,231,893 Immunosuppressive and tumour-suppressive bone marrow factor 6,228,639 Vectors and methods for the mutagenesis of mammalian genes 6,228,591 Polycystic kidney disease PKD2 gene and uses thereof 6,228,583 Assays for compounds which extend life span 6,225,525 ATP-binding cassette transporter (ABC1) modified transgenic mice 6,225,456 Ras suppressor SUR-5 6,225,121 Eukaryotic transposable element 6,225,101 Isolated Myt1 polypeptide 6,225,085 LRSG protein and nucleic acid molecules and uses therefor 6,224,870 Vaccine compositions and methods of modulating immune responses 6,222,029 5′ ESTs for secreted proteins expressed in brain 6,221,647 Efficient construction of gene targeting using phage-plasmid recombination 6,221,643 Methods for diagnosis and treatment of Bloom’s syndrome 6,218,510 B7-1 and B7-2 polypeptides 6,218,356 Neural receptor tyrosine kinase 6,218,181 Retroviral packaging cell line 6,218,162 SH2-containing inositol-phosphatase 6,215,041 Cloning using donor nuclei from a non-quiesecent somatic cells 6,214,597 CSAPK-3 protein and uses therefor 6,210,921 CAR: a novel coxsackievirus and adenovirus receptor 6,207,876 Adenosine deaminase deficient transgenic mice and methods for the use thereof 6,207,450 Glaucoma therapeutics and diagnostics based on a novel human transcription factor 6,207,431 Glutamine:fructose-6-phosphate amidotransferase, its production and use 6,204,432 PA28 modified transgenic mice 6,204,364 Hybrid cytokines 6,204,035 Methods and compositions to alter the cell surface expression of phosphatidylserine and other clot-promoting plasma membrane phospholipids 6,204,013 MSP-5 nucleic acid molecules and uses therefor 6,201,168 Pathogenesis of cardiomyopathy 6,201,107 Cystic fibrosis gene 6,200,806 Primate embryonic stem cells 6 6,200,780 Human interferon-.epsilon.(IFN-.epsilon.), a type I interferon 6,200,770 Protein kinase molecules and uses therefor 6,200,769 Mammalian CDP-diacylglycerol synthase 6,200,567 Therapeutic agents as cytokine antagonists and agonists 6,197,928 Fluorescent protein sensors for detection of analytes 6,197,751 Thymosin .alpha.1 promotes tissue repair, angiogenesis and cell migration 6,197,578 Cells expressing both human CD4 and a human fusion accessory factor associated with HIV infection 6,197,575 Vascularized perfused microtissue/micro-organ arrays 6,197,551 Spoil-1 protein and nucleic acid molecules and uses therefor 6,197,530 GPR10 as a target for identifying weight modulating compounds 6,194,635 Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine 6,194,633 Non-human animal having a functionally disrupted SLP-76 gene 6,194,212 Vectors comprising SAR elements 6,194,152 Prostate tumor polynucleotide compositions and methods of detection thereof 6,194,151 Molecules of the TNF receptor superfamily and uses therefor 6,191,154 Compositions and methods for the treatment of Alzheimer’s disease, central nervous system injury, and inflammatory diseases 6,190,910 Mouse embryonic stem cell lines 6,190,887 Expression of an exogenous gene in a mammalian cell by use of a non-mammalian DNA virus having an altered coat protein 6,190,874 Methods for identifying compounds that bind to CSAPK-1 6,187,992 Transgenic mouse having a disrupted amyloid precursor protein gene 6,184,436 Transgenic mice expressing HIV-1 in immune cells 6,184,035 Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells 6,183,993 Complement-resistant non-mammalian DNA viruses and uses thereof 6,183,962 Protein kinase molecules and uses therefor 6,183,744 Immunotherapy of B-cell malignancies using anti-CD22 antibodies 6,180,358 Methods for identifying compounds that bind to CSPAK-2 6,177,244 NPG-1 gene that is differentially expressed in prostate tumors 6,174,682 Thioredoxin family active site molecules and uses therefor 6,174,674 Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene 6,172,278 Ikaros transgenic cells and mice 6,171,824 Hybrid cytokines 6,168,933 Phospholipid transfer protein 6,166,289 IRAK modified transgenic animals 6,166,192 PGC-1, a novel brown fat PPAR.gamma. coactivator 6,166,178 Telomerase catalytic subunit 6,165,755 Chicken neuropeptide gene useful for improved poultry production 6,165,748 Frazzled nucleotide sequences and expression products 6,165,719 hKCa3/KCNN3 small conductance calcium activated potassium channel: a diagnostic marker and therapeutic target 6,162,963 Generation of Xenogenetic antibodies 6,162,616 Multidrug resistance-associated polypeptide 6,159,691 Assay for a putative regulator of cell cycle progression 6,156,733 Use of leukemia inhibitory factor and endothelin antagonists 6,156,569 Prolonged culturing of avian primordial germ cells (PGCs) using specific growth factors, use thereof to produce chimeric avians 6,156,306 Pancreatic .beta.-cells for allogeneic transplantation without immunosuppression 6,153,428 .alpha.(1,3) galactosyltransferase negative porcine cells 6,153,417 CSAPK-1 protein and uses therefor 6,150,169 Expression of the heterologous genes according to a targeted expression profile 6,147,276 Quiescent cell populations for nuclear transfer in the production of non-human mammals and non-human mammalian embryos 6,146,888 Method of enriching for mammalian stem cells 6,146,841 Methods for identifying compounds that bind to CSAPK-3 molecules and fragments thereof 6,146,832 Protein kinase molecules and uses therefor 6,143,566 Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof 6,143,540 Molecules of the HKID-1-related protein family and uses thereof 6,140,121 Methods and compositions to improve germ cell and embryo survival and function 6,140,083 Leptospiral outer membrane protein, LipL46 6,140,056 MSP-18 protein and nucleic acid molecules and uses therefor 6,139,835 Homologous recombination for allogeneic donor cells 6,136,964 Mammalian lysophosphatidic acid acyltransferase 6,136,958 Antibodies to vertebrate smoothened proteins 6,136,954 Tetracycline-inducible transcriptional activator fusion proteins 6,136,539 Compositions and methods for the inhibition of MUC-5 mucin gene expression 6,136,040 Animal model with disrupted FGF-9 gene 6,133,503 Mammalian artificial chromosomes and methods of using same.
The Potential is Real – The Confusion is Overwhelming – The Passion is Blinding. So What do we do? Is sticking our heads in the sand of ignorance the right approach?
We wanted to explore what is going on in the intellectual property front of the embryonic stem cell landscape. This will provide insight into what the research and business enterprises focus in. it will shed light on directions, possibilities, and actualities.
Note though, that not all that’s patented is all that there is … for example the Geron Corporation is associated with only the following patents associated directly with embryonic stem cells.
Clearly, from title analysis, Mammalian Telomerase is a one of their major keys to the lock.
PAT. NO. Title 1 6,258,535 Mammalian telomerase 2 6,166,178 Telomerase catalytic subunit 3 6,147,276 Quiescent cell populations for nuclear transfer in the production of non-human mammals and non-human mammalian embryos 4 6,054,575 Mammalian telomerase RNA gene promoter 5 5,958,680 Mammalian telomerase 6 5,837,857 Mammalian telomerase 7 5,776,679 Assays for the DNA component of human telomerase 8 5,583,016 Mammalian telomerase
LISTING OF THE MOST CURRENT U.S. PATENTS on EMBRYONIC STEM CELLS
PATENT # Title 6,274,363 Phosphatidylcholine phospholipase D 6,274,362 RGS-containing molecules and uses thereof 6,274,338 Human c-Maf compositions and methods of use thereof 6,274,309 Method for the modulation of acid-sphingomyelinase-related apoptosis 6,271,436 Cells and methods for the generation of transgenic pigs 6,271,348 Tetracycline-inducible transcriptional inhibitor fusion proteins 6,271,341 Transcriptional activators with graded transactivation potential 6,270,778 Melanoma antigens and their use in diagnostic and therapeutic methods 6,268,135 Phospholipase molecule and uses therefor 6,268,130 RP compositions and diagnostic uses therefor 6,265,564 Expressed ligand-vascular intercellular signalling molecule 6,265,546 Prostate cancer gene 6,262,337 Transgenic animal with recombinant vascular endothelial growth factor B (VEGF-B DNA) and uses thereof 6,262,235 Leptospiral outer membranes protein, LipL46 6,262,035 Gene replacement therapy for muscular dystrophy 6,261,818 CARK protein and nucleic acid molecules and uses therefor 6,258,998 Method of cloning porcine animals 6,258,582 CSAPTP nucleic acid molecules and uses therefor 6,258,557 Smooth muscle cell LIM promoter 6,258,535 Mammalian telomerase 6,255,473 Presenilin-1 gene promoter 6,255,458 High affinity human antibodies and human antibodies against digoxin 6,255,112 Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells 6,252,136 Transgenic organisms having tetracycline-regulated transcriptional regulatory systems 6,252,132 Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor 6,252,051 ErbB4 receptor-specific neuregulin related ligand antibodies and uses therefor 6,251,671 Compositions and methods of making embryonic stem cells 6,248,934 Gene trap vectors 6,248,527 Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E 6,245,969 Receptor kinase, Bin1 6,245,566 Human embryonic germ cell line and methods of use 6,245,529 Testis-specific cystatin-like protein cystatin T 6,245,527 Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof 6,242,667 Transgenic organisms having tetracycline-regulated transcriptional regulatory porno mexicano systems 6,242,588 Testis specific glycoprotein zpep10 6 6,242,236 Method of promoting enzyme diversity 6,239,326 Sparc-deficient transgenic mice 6,238,903 SH2-containing inositol-phosphatase 6,238,881 Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase