Charité - Universitätsmedizin Berlin

Department of Experimental Neurology &
Center for Stroke Research Berlin
Chariteplatz 1
10098 Berlin
Germany

Experimental Neurology
Center for Stroke Research Berlin

The Center for Stroke Research at Humboldt University is embedded in one of the oldest, most prestigious, and largest academic hospitals in Europe, the Charité. For almost two decades the Dirnagl group has focussed on mechanisms of damage and protection in stroke. The full range of methodological tools is available, including own animal facility, behavioural unit, 2-photon microscopy, 7T-µMRI, µSPECT-CT, µPET, etc. Importantly, the Center for Stroke Research also incorporates 3 stroke units, with approx. 1600 stroke patients each year, and a dedicated research 3T MRI on the stroke unit. The Charité group performs investigator initiated stroke trials based on their discoveries, and owns a number of stroke related patents. Drs.Dirnagl and Endres are members of numerous boards of journals and scientific societies devoted to stroke research. Dr.Dirnagl is coordinating the Early Stage Training (EST) 'CORTEX', in which 8 European Neuroscience schools joined to offer an international PhD training funded by the European Union. A substantial fraction of the research in this EST is focussed on stroke.

Role in Project

Ulrich Dirnagl leads the consortium, and coordinates WP04. Furthermore, together with Andreas Meisel and Matthias Endres he also takes part in all other WPs. Our main tasks within the project will be:

1. definition of the immuno- and neuromodulatory properties of antibiotics,
2. the elucidation of mechanisms by which adaptive and innate immunity are affected by stroke and how the immune system in turn affects tissue damage, endogenous protection, and repair in the brain,
3. discover novel, HIF1 induced neuroprotective proteins, and
4. contribute patient serum and blood samples of highly characterized stroke patient populations for interventions,
5. characterise long-term behavioural and emotional abnormalities after brain ischaemia and evaluate them as possible endpoints for therapeutic interventions.
6. other tasks are the development of co-morbidity models of stroke,
7. contributions to cellular and molecular imaging and
8. training aspects within the consortium.

Project Leader

Prof. Dr. Ulrich Dirnagl Co-ordinator of ARISE Phone: +49 30 450 560 134 Fax: +49 30 450 560 942 Contact

Prof. Dr. Matthias Endres Phone: +49 30 450 560 257 Fax: +49 30 450 560 942 Contact

Prof. Dr. Andreas Meisel Phone: +49 30 450 560 020 Fax: +49 30 450 560 932 Contact

Ferah Yildirim, MSc Phone: +49 30 450 560 014 Contact

Phillip Mergenthaler, MD Phone: +49 30 450 560 020 Contact

Dr. Karen Gertz Phone: +49 030 450 560 014 Contact

Dr. Vincent Prinz Phone: +49 30 450 560 137 Contact

Anna Lena Dätwyler, MSc Phone: +49 30 450 560 137 Contact

Anja Kahl, cand.med.