Lund University lund

Wallenberg Neurosciences Center
BMC, Sölvegatan 17
221 84 Lund
Sweden

Laboratory for Experimental Brain Research
Section of Restorative Neurology

Lund University has a strong tradition in pioneering stroke research, which dates back to the late
1960s. The venue of stroke research in Lund has since then expanded to the Wieloch and Lindvall
groups. These are complementary laboratories located at the Wallenberg Neuroscience Center at
Lund University. In ESN, the two groups form a team addressing various molecular and cellular
aspects of brain protection and brain repair after stroke. The Wieloch group focuses on studies of
the spectacular protective effect of mild hypothermia and on the processes involved in functional
recovery of surviving cells.
This group will contribute with in vitro (organotypic) and animal models of stroke, post-stroke brain
genomic analysis, and live cell and in vivo 2-photon microscopy imaging. The Lindvall group focuses
on the regulation of neurogenesis from endogenous neural stem cells after stroke, the role of
inflammation and the analysis of function of new stroke-generated neurons at the cellular and
behavioural level. This group will contribute with expertise in neural stem cell biology, clinical cell
replacement therapy and translational research, morphological analysis of neurogenesis in the
post-stroke brain, patch-clamp electrophysiology for analysis of functional synaptic connectivity
of new neurons.

Our tasks in the ESN are:
- To identify mechanisms by which hypothermia induces neuroprotection
- To study the spine dynamics and function in the peri-infarct area
- To study gliosis and wound healing
- To study factors regulating neurogenesis after stroke
- To study the influence of inflammation on the neurogenic response
- To identify factors that stimulate regeneration and repair after stroke and develop
systems for their delivery

Project Staff

Prof. Tadeusz Wieloch
Head of Laboratory for experimental Brain Research
Team leader
Phone: +46 46 222 06 00
Fax: +46 46 222 06 15
Contact

Prof. Olle Lindvall
Head of the Section of Restorative Neurology
Phone: +46 46 222 05 43
Fax: +46 46 222 05 60
Contact

Prof. Zaal Kokaia
Lund Strategic Research Center
for Stem Cell Biology and Cell Therapy
Phone: +46 46 222 02 76
Fax: +46 46 222 05 60
Contact

Assistant Prof. Hakan Toresson
Laboratory for experimental Brain Research
Phone: +46 46 222 06 13
Fax: +46 46 222 06 15
Contact

Dr. Karsten Ruscher
Laboratory for experimental Brain Research
Phone: +46 46 222 06 09
Fax: +46 46 222 06 15
Contact

Dr. Nuno Andrade
Section of Restorative Neurology
Phone: +46 46 222 05 50
Fax: +46 46 222 05 60
Contact

MD, Ursula Heldmann
PhD-student, Section of Restorative Neurology
Phone: +46 46 222 05 48
Fax: +46 46 222 05 60
Contact