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  SE-171 77 Stockholm, Sweden Phone: +46 8-524 800 00 Fax: +46 8-31 11 01 Homepage Karolinska Institutet is the largest medical university in Sweden with regard to research and education and one of the largest in Europe. SITS International and the Stroke Research Unit of the Karolinska Institutet and KarolinskaUniversity Hospital are embedded within one of the oldest neurology departments in Europe, established in 1881. Since 1988 the Stroke Research unit (Director Prof. Nils Wahlgren) has focussed on clinical trials in acute stroke and stroke prevention, in particular within neuroprotection and reperfusion. Since 1996 an interactive database for accumulation of clinical data on reperfusion therapy in stroke patients has been developed as a tool for identification of safety alerts within evidence based stroke therapies and for understanding of factors facilitating broad implementation of such interventions. Being primarily a resource for Scandinavian and North European stroke centres, the network of affiliated clinical centres was extended considerably after 2002, when the EU Commission decided to provide a provisional licence for thrombolytic therapy on the condition that all patients treated in EU during three years should be monitored for safety through SITS. Since 1996 Karolinska has organised biannual meetings, the Karolinska Stroke Update, for development of consensus statements regarding new randomised controlled trial evidence in stroke therapy. Role in the ProjectThe main tasks of the Karolinska Institutet will be to provide support for coordination and data management to translational projects extending into clinical trials phase I-II, to support establishment of an appropriate network of clinical centres for that purpose, to give advice to preclinical projects with regard to translational aspects and to evaluate candidates for therapeutic intervention in stroke. The SITS technical platform will be adapted to the requirements of randomised controlled trials settings and members of the SITS network of clinical centres will be screened for participation. Project Leader
Project Staff
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