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Ghent designs and evaluates micro- and nanoparticles for drug delivery and diagnostics. With regard to gene therapy, their focus is on the mobility, and the stability, of non-viral gene complexes and in the extra- and intra-cellular matrix. To better understand the cellular behaviour of non-viral gene DNA complexes, they are currently evaluating the potential of new techniques. For more than seven years now, the research group of Prof. De Smedt explores the extent to which advanced microscopy technologies (especially FCS, FRAP, single particle tracking) allow the biophysical properties of non-viral vector/DNA complexes to be studied in vitro and in vivo. Besides the design and evaluation of DNA containing particles, this research group works on the development of exploding (micron sized) particles for pulsed delivery (of vaccines) after parenteral administration.They also defined a new concept for 'encoding’ microparticles, which was published in Nature Materials.
Role in ProjectThis partner will contribute to the evaluation of new ultrasound techniques for opening the blood-brain-barrier (BBB). A major is aim to provide an ultrasound based platform for delivery of therapeutic agents through the BBB.
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