The most recent US patents on stem cells

6,132,718  Multi-stage cascade boosting vaccine  
6,130,364  Production of antibodies using Cre-mediated site-specific recombination  
6,130,316  Fusion proteins of novel CTLA4/CD28 ligands and uses therefore  
6,127,598  NKX-2.2 and NKX-6.1 transgenic mouse models for diabetes, depression, and obesity  
6,121,415  ErbB4 receptor-specific neuregolin related ligands and uses therefor  
6,121,030  CSAPK-2 protein and uses therefor  
6,118,045  Lysosomal proteins produced in the milk of transgenic animals  
6,117,654  Nucleic acid molecules encoding Tango-77-polypeptides  
6,117,650  Assay for cardiac hypertrophy  
6,114,598  Generation of xenogeneic antibodies  
6,114,123  Lipocalin family protein  
6,111,092  Nucleic acid molecules encoding DRT111 and uses thereof   
6,110,739  Method to produce novel embryonic cell populations  
6,110,718  Mammalian putative phosphatidylinositol-4-phosphate-5-kinase  
6,107,543  Culture of totipotent embryonic inner cells mass cells and production of bovine animals  
6,107,472  Receptor-type tyrosine kinase-like molecules  
6,107,088  XAF genes and polypeptides: methods and reagents for modulating apoptosis  
6,106,832  Treatment of individuals exhibiting defective CD40L  
6,103,890  Enzymatic nucleic acids that cleave C-fos  
6,103,523  Pluripotent rabbit cell lines and method of making  
6,100,445  Transgenic knockout mouse having functionally disrupted interleukin-1.beta. converting enzyme gene  
6,100,444  Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen  
6,100,443  Universal donor cells  
6,093,545  Methods for detecting nucleic acid molecules encoding a member of the muscarinic family of receptors  
6,093,393  Methods for preparing and using clonogenic fibroblasts and transfected clonogenic fibroblasts  
6,091,001  Production of antibodies using Cre-mediated site-specific recombination  
6,090,629  Efficient construction of gene targeting using phage-plasmid recombination  
6,090,622  Human embryonic pluripotent germ cells  
6,090,561  NF-AT-interacting protein NIP45 and methods of use therefor  
6,090,381  Stimulation of an immune response with antibodies labeled with the . .alpha-galactosyl epitope  
6,087,555  Mice lacking expression of osteoprotegerin  
6,087,166  Transcriptional activators with graded transactivation potential  
6,087,107  Therapeutics and diagnostics for congenital heart disease based on a novel human transcription factor  
6,086,900  Methods and compositions for using membrane-penetrating proteins to carry materials across cell membranes  
6,084,084  Human metabotropic glutamate receptor  
6,084,067  CTLA4/CD28 ligands and uses therefor  
6,083,911  Arenavirus receptor and methods of use  
6,080,911  Mice models of growth hormone insensitivity  
6,080,910  Transgenic knockout animals lacking IgG3  
6,080,550  Isolation and characterization of Agouti: a diabetes/obesity related gene  
6,077,990  PAR2 modified transgenic mice  
6,077,936  Multidrug resistance-associated polypeptide  
6,077,686  Shc proteins  
6,077,675  Human metabotropic glutamate receptor  
6,077,667  Method for chromosomal rearrangement by consecutive gene targeting of two recombination substrates to the deletion endpoints  
6,075,181  Human antibodies derived from immunized xenomice  
6,074,849  Polynucleotides encoding human CTLA-8 related proteins  
6,074,845  Nucleic acid encoding a bovine calcitonin receptor-like receptor (BECRLR)  
6,069,297  Glucose-6-phosphate dehydrogenase deficient mice and methods of using same  
6,069,010  High throughput gene inactivation with large scale gene targeting  
6,066,778  Transgenic mice expressing APC resistant factor V  
6,063,983  Monoclonal lymphocytes and methods of use  
6,063,359  Method for determining oncogenic activity of a substance  
6,060,642  Serotonin 5-HT6 receptor knockout mouse  
6,060,590  Chitinase related proteins and methods of use  
6,060,310  Transcription factor decoy and tumor growth inhibitor  
6,060,263  Mammalian lysophosphatidic acid acyltransferase  
6,057,489  MmRad51-deficient cells and transgenic mice  
6,057,128  MU-1, member of the cytokine receptor family  
6,054,575  Mammalian telomerase RNA gene promoter  
6,051,690  NSP molecules  
6,051,688  Isolated human metabotropic glutamate receptor Mglur-8  
6,051,403  Nsp molecules  
6,046,048  Apo-2 ligand  
6,046,035  Polynucleotides encoding a cardiotrophin-like cytokine  
6,043,344  Human CTLA-8 and uses of CTLA-8-related proteins  
6,043,040  Csak-3 nucleic acid molecules and uses therefor  
6,037,168  Microbiological assembly comprising resealable closure means  
6,037,148  MTBX protein and nucleic acid molecules and uses therefor  
6,034,062  Bone morphogenetic protein (BMP)-9 compositions and their uses  
6,033,861  Methods for obtaining nucleic acid containing a mutation  
6,031,088  Polycystic kidney disease PKD2 gene and uses thereof  
6,031,078  MTbx protein and nucleic acid molecules and uses therefor  
6,031,003  Calcium receptor-active molecules  
6,030,833  Transgenic swine and swine cells having human HLA genes  
6,030,617  Use of growth differentiation factor-9 (GDF-9) to inhibit oocyte maturation  
6,028,244  Defective platelet activation in G.alpha..sub.q deficient mice  
6,028,243  Mice and cells with a homozygous disruption in the RNase L gene and methods therefore  
6,028,184  Pax6 and Pax4 nucleic acid mixtures  
6,027,917  Bone morphogenetic protein (BMP)-17 and BMP-18 compositions  
6,025,157  Neurturin receptor  
6,022,708  Fused  
6,020,194  DNA encoding a Myt1 polypeptide  
6,015,671  Myocardial grafts and cellular compositions  
6,015,670  Methods for identifying a mutation in a gene of interest without a phenotypic guide using ES cells  
6,015,554  Method of reconstituting human lymphoid and dendritic cells  
6,013,468  RNA component of telomerase  
6,011,197  Method of cloning bovines using reprogrammed non-embryonic bovine cells  
6,011,068  Calcium receptor-active molecules  
6,010,853  Siva genes, novel genes involved in CD27-mediated apoptosis  
6,008,434  Growth differentiation factor-11 transgenic mice  
6,004,941  Methods for regulating gene expression  
6,002,066  H2-M modified transgenic mice  
6,001,588  Introns and exons of the cystic fibrosis gene and mutations thereof  
5,998,204  Fluorescent protein sensors for detection of analytes  
5,998,187  Receptor tyrosine kinase  
5,998,136  Selection systems and methods for identifying genes and gene products involved in cell proliferation  
5,994,620  Induced chromosomal deletion  
5,994,619  Production of chimeric bovine or porcine animals using cultured inner cell mass cells  
5,994,618  Growth differentiation factor-8 transgenic mice  
5,994,523  Melanoma antigens and their use in diagnostic and therapeutic methods  
5,994,130  Multidrug resistance-associated polypeptide  
5,994,075  Methods for identifying a mutation in a gene of interest without a phenotypic guide  
5,990,281  Vertebrate smoothened proteins  
5,989,914  Integration cassette for improvement of transgenesis in eukaryotes  
5,986,056  Chordin compositions  
5,985,660  Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation  
5,985,659  Embryonic stem cell lines obtained from C3H/HeN and DBA/1J mouse strains  
5,985,615  Directed switch-mediated DNA recombination  
5,985,602  Secreted proteins and polynucleotides encoding them  
5,981,830  Knockout mice and their progeny with a disrupted hepsin gene  
5,981,277  Polypeptides and peptides, nucleic acids coding for them, and their use in the field of tumor therapy, inflammation or immunology

More US patents on stem cells

6,238,429  Biologic cabling  
6,235,970  CICM cells and non-human mammalian embryos prepared by nuclear transfer of a proliferating differentiated cell or its nucleus  
6,235,969  Cloning pigs using donor nuclei from non-quiescent differentiated cells  
6,235,878  Fas ligand-like protein, its production and use  
6,235,708  Testis-specific cystatin-like protein cystatin T  
6,235,481  Polynucleotides encoding calpain 10  
6,231,893  Immunosuppressive and tumour-suppressive bone marrow factor  
6,228,639  Vectors and methods for the mutagenesis of mammalian genes  
6,228,591  Polycystic kidney disease PKD2 gene and uses thereof  
6,228,583  Assays for compounds which extend life span  
6,225,525  ATP-binding cassette transporter (ABC1) modified transgenic mice  
6,225,456  Ras suppressor SUR-5  
6,225,121  Eukaryotic transposable element  
6,225,101  Isolated Myt1 polypeptide  
6,225,085  LRSG protein and nucleic acid molecules and uses therefor  
6,224,870  Vaccine compositions and methods of modulating immune responses  
6,222,029  5′ ESTs for secreted proteins expressed in brain  
6,221,647  Efficient construction of gene targeting using phage-plasmid recombination  
6,221,643  Methods for diagnosis and treatment of Bloom’s syndrome  
6,218,510  B7-1 and B7-2 polypeptides  
6,218,356  Neural receptor tyrosine kinase  
6,218,181  Retroviral packaging cell line  
6,218,162  SH2-containing inositol-phosphatase  
6,215,041  Cloning using donor nuclei from a non-quiesecent somatic cells  
6,214,597  CSAPK-3 protein and uses therefor  
6,210,921  CAR: a novel coxsackievirus and adenovirus receptor  
6,207,876  Adenosine deaminase deficient transgenic mice and methods for the use thereof  
6,207,450  Glaucoma therapeutics and diagnostics based on a novel human transcription factor  
6,207,431  Glutamine:fructose-6-phosphate amidotransferase, its production and use  
6,204,432  PA28 modified transgenic mice  
6,204,364  Hybrid cytokines  
6,204,035  Methods and compositions to alter the cell surface expression of phosphatidylserine and other clot-promoting plasma membrane phospholipids  
6,204,013  MSP-5 nucleic acid molecules and uses therefor  
6,201,168  Pathogenesis of cardiomyopathy  
6,201,107  Cystic fibrosis gene  
6,200,806  Primate embryonic stem cells  
6 6,200,780  Human interferon-.epsilon.(IFN-.epsilon.), a type I interferon  
6,200,770  Protein kinase molecules and uses therefor  
6,200,769  Mammalian CDP-diacylglycerol synthase  
6,200,567  Therapeutic agents as cytokine antagonists and agonists  
6,197,928  Fluorescent protein sensors for detection of analytes  
6,197,751  Thymosin .alpha.1 promotes tissue repair, angiogenesis and cell migration  
6,197,578  Cells expressing both human CD4 and a human fusion accessory factor associated with HIV infection  
6,197,575  Vascularized perfused microtissue/micro-organ arrays  
6,197,551  Spoil-1 protein and nucleic acid molecules and uses therefor  
6,197,530  GPR10 as a target for identifying weight modulating compounds  
6,194,635  Embryonic germ cells, method for making same, and using the cells to produce a chimeric porcine  
6,194,633  Non-human animal having a functionally disrupted SLP-76 gene  
6,194,212  Vectors comprising SAR elements  
6,194,152  Prostate tumor polynucleotide compositions and methods of detection thereof  
6,194,151  Molecules of the TNF receptor superfamily and uses therefor  
6,191,154  Compositions and methods for the treatment of Alzheimer’s disease, central nervous system injury, and inflammatory diseases  
6,190,910  Mouse embryonic stem cell lines  
6,190,887  Expression of an exogenous gene in a mammalian cell by use of a non-mammalian DNA virus having an altered coat protein  
6,190,874  Methods for identifying compounds that bind to CSAPK-1  
6,187,992  Transgenic mouse having a disrupted amyloid precursor protein gene  
6,184,436  Transgenic mice expressing HIV-1 in immune cells  
6,184,035  Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells  
6,183,993  Complement-resistant non-mammalian DNA viruses and uses thereof  
6,183,962  Protein kinase molecules and uses therefor  
6,183,744  Immunotherapy of B-cell malignancies using anti-CD22 antibodies  
6,180,358  Methods for identifying compounds that bind to CSPAK-2  
6,177,244  NPG-1 gene that is differentially expressed in prostate tumors  
6,174,682  Thioredoxin family active site molecules and uses therefor  
6,174,674  Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene  
6,172,278  Ikaros transgenic cells and mice  
6,171,824  Hybrid cytokines  
6,168,933  Phospholipid transfer protein  
6,166,289  IRAK modified transgenic animals  
6,166,192  PGC-1, a novel brown fat PPAR.gamma. coactivator  
6,166,178  Telomerase catalytic subunit  
6,165,755  Chicken neuropeptide gene useful for improved poultry production  
6,165,748  Frazzled nucleotide sequences and expression products  
6,165,719  hKCa3/KCNN3 small conductance calcium activated potassium channel: a diagnostic marker and therapeutic target  
6,162,963  Generation of Xenogenetic antibodies  
6,162,616  Multidrug resistance-associated polypeptide  
6,159,691  Assay for a putative regulator of cell cycle progression  
6,156,733  Use of leukemia inhibitory factor and endothelin antagonists  
6,156,569  Prolonged culturing of avian primordial germ cells (PGCs) using specific growth factors, use thereof to produce chimeric avians  
6,156,306  Pancreatic .beta.-cells for allogeneic transplantation without immunosuppression  
6,153,428  .alpha.(1,3) galactosyltransferase negative porcine cells  
6,153,417  CSAPK-1 protein and uses therefor  
6,150,169  Expression of the heterologous genes according to a targeted expression profile  
6,147,276  Quiescent cell populations for nuclear transfer in the production of non-human mammals and non-human mammalian embryos  
6,146,888  Method of enriching for mammalian stem cells  
6,146,841  Methods for identifying compounds that bind to CSAPK-3 molecules and fragments thereof  
6,146,832  Protein kinase molecules and uses therefor  
6,143,566  Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof  
6,143,540  Molecules of the HKID-1-related protein family and uses thereof  
6,140,121  Methods and compositions to improve germ cell and embryo survival and function  
6,140,083  Leptospiral outer membrane protein, LipL46  
6,140,056  MSP-18 protein and nucleic acid molecules and uses therefor  
6,139,835  Homologous recombination for allogeneic donor cells  
6,136,964  Mammalian lysophosphatidic acid acyltransferase  
6,136,958  Antibodies to vertebrate smoothened proteins  
6,136,954  Tetracycline-inducible transcriptional activator fusion proteins  
6,136,539  Compositions and methods for the inhibition of MUC-5 mucin gene expression  
6,136,040  Animal model with disrupted FGF-9 gene  
6,133,503  Mammalian artificial chromosomes and methods of using same.

EMBRYONIC STEM CELLS: Does it all start here? What does the patent landscape look like?

The Potential is Real – The Confusion is Overwhelming – The Passion is Blinding.  So What do we do? Is sticking our heads in the sand of ignorance the right approach?

We wanted to explore what is going on in the intellectual property front of the embryonic stem cell landscape.  This will provide insight into what the research and business enterprises focus in.  it will shed light on directions, possibilities, and actualities.

Note though, that not all that’s patented is all that there is … for example the Geron Corporation is associated with only the following patents associated directly with embryonic stem cells.
Clearly, from title analysis, Mammalian Telomerase is a one of their major keys to the lock.
PAT. NO.  Title 
1 6,258,535  Mammalian telomerase  
2 6,166,178  Telomerase catalytic subunit  
3 6,147,276  Quiescent cell populations for nuclear transfer in the production of non-human mammals and non-human mammalian embryos  
4 6,054,575  Mammalian telomerase RNA gene promoter  
5 5,958,680  Mammalian telomerase  
6 5,837,857  Mammalian telomerase  
7 5,776,679  Assays for the DNA component of human telomerase  
8 5,583,016  Mammalian telomerase
PATENT #  Title 
6,274,363  Phosphatidylcholine phospholipase D  
6,274,362  RGS-containing molecules and uses thereof  
6,274,338  Human c-Maf compositions and methods of use thereof  
6,274,309  Method for the modulation of acid-sphingomyelinase-related apoptosis  
6,271,436  Cells and methods for the generation of transgenic pigs  
6,271,348  Tetracycline-inducible transcriptional inhibitor fusion proteins  
6,271,341  Transcriptional activators with graded transactivation potential  
6,270,778  Melanoma antigens and their use in diagnostic and therapeutic methods  
6,268,135  Phospholipase molecule and uses therefor  
6,268,130  RP compositions and diagnostic uses therefor  
6,265,564  Expressed ligand-vascular intercellular signalling molecule  
6,265,546  Prostate cancer gene  
6,262,337  Transgenic animal with recombinant vascular endothelial growth factor B (VEGF-B DNA) and uses thereof  
6,262,235  Leptospiral outer membranes protein, LipL46  
6,262,035  Gene replacement therapy for muscular dystrophy  
6,261,818  CARK protein and nucleic acid molecules and uses therefor  
6,258,998  Method of cloning porcine animals  
6,258,582  CSAPTP nucleic acid molecules and uses therefor  
6,258,557  Smooth muscle cell LIM promoter  
6,258,535  Mammalian telomerase  
6,255,473  Presenilin-1 gene promoter  
6,255,458  High affinity human antibodies and human antibodies against digoxin  
6,255,112  Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells  
6,252,136  Transgenic organisms having tetracycline-regulated transcriptional regulatory systems  
6,252,132  Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor  
6,252,051  ErbB4 receptor-specific neuregulin related ligand antibodies and uses therefor  
6,251,671  Compositions and methods of making embryonic stem cells  
6,248,934  Gene trap vectors  
6,248,527  Method of detecting risk of type II diabetes based on mutations found in carboxypeptidase E  
6,245,969  Receptor kinase, Bin1  
6,245,566  Human embryonic germ cell line and methods of use  
6,245,529  Testis-specific cystatin-like protein cystatin T  
6,245,527  Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof  
6,242,667  Transgenic organisms having tetracycline-regulated transcriptional regulatory porno mexicano systems  
6,242,588  Testis specific glycoprotein zpep10  
6 6,242,236  Method of promoting enzyme diversity  
6,239,326  Sparc-deficient transgenic mice  
6,238,903  SH2-containing inositol-phosphatase  
6,238,881  Nucleic acids and polypeptides related to a guanine exchange factor of Rho GTPase